Articles Accessed Most Frequently

These are the Top 20 Papers (by download) for the 30 days preceding May 8, 2008. You can see the summaries if you are registered, or full text and PDFs if you have subscribed.

1.  Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
Ruprecht Wiedemeyer, Cameron Brennan, Timothy P. Heffernan, Yonghong Xiao, John Mahoney, Alexei Protopopov, Hongwu Zheng, Graham Bignell, Frank Furnari, Webster K. Cavenee, William C. Hahn, Koichi Ichimura, V. Peter Collins, Gerald C. Chu, Michael R. Stratton, Keith L. Ligon, P. Andrew Futreal and Lynda Chin
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
2.  A Perivascular Niche for Brain Tumor Stem Cells
Christopher Calabrese, Helen Poppleton, Mehmet Kocak, Twala L. Hogg, Christine Fuller, Blair Hamner, Eun Young Oh, M. Waleed Gaber, David Finklestein, Meredith Allen, Adrian Frank, Ildar T. Bayazitov, Stanislav S. Zakharenko, Amar Gajjar, Andrew Davidoff and Richard J. Gilbertson
[Summary]  [Fulltext]  [PDF] 
January,  
11 (1)
3.  Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity
Zhang Weihua, Rachel Tsan, Wei-Chien Huang, Qiuyu Wu, Chao-Hua Chiu, Isaiah J. Fidler and Mien-Chie Hung
[Summary]  [Fulltext]  [PDF] 
May 06, 2008 
13 (5)
4.  Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization
Judith Schmiedel, Andree Blaukat, Shiqing Li, Thorsten Knöchel and Kathryn M. Ferguson
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
5.  Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells
Peggy Kirstetter, Mikkel B. Schuster, Oksana Bereshchenko, Susan Moore, Heidi Dvinge, Elke Kurz, Kim Theilgaard-Mönch, Robert Månsson, Thomas Å. Pedersen, Thomas Pabst, Evelin Schrock, Bo T. Porse, Sten Eirik W. Jacobsen, Paul Bertone, Daniel G. Tenen and Claus Nerlov
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
6.  Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis
Maresa Caunt, Judy Mak, Wei-Ching Liang, Scott Stawicki, Qi Pan, Raymond K. Tong, Joe Kowalski, Calvin Ho, Hani Bou Reslan, Jed Ross, Leanne Berry, Ian Kasman, Constance Zlot, Zhiyong Cheng, Jennifer Le Couter, Ellen H. Filvaroff, Greg Plowman, Franklin Peale, Dorothy French, Richard Carano, Alexander W. Koch, Yan Wu, Ryan J. Watts, Marc Tessier-Lavigne and Anil Bagri
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
7.  Selective Inhibition of JAK2-Driven Erythroid Differentiation of Polycythemia Vera Progenitors
Ifat Geron, Annelie E. Abrahamsson, Charlene F. Barroga, Edward Kavalerchik, Jason Gotlib, John D. Hood, Jeffrey Durocher, Chi Ching Mak, Glenn Noronha, Richard M. Soll, Ayalew Tefferi, Ken Kaushansky and Catriona H.M. Jamieson
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
8.  The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis
Angeles Duran, Juan F. Linares, Anita S. Galvez, Kathryn Wikenheiser, Juana M. Flores, Maria T. Diaz-Meco and Jorge Moscat
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
9.  Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
Kurtis E. Bachman, Ben Ho Park, Ina Rhee, Harith Rajagopalan, James G. Herman, Stephen B. Baylin, Kenneth W. Kinzler and Bert Vogelstein
[Summary]  [Fulltext]  [PDF] 
January,  
3 (1)
10.  Regulation of In Situ to Invasive Breast Carcinoma Transition
Min Hu, Jun Yao, Danielle K. Carroll, Stanislawa Weremowicz, Haiyan Chen, Daniel Carrasco, Andrea Richardson, Shelia Violette, Tatiana Nikolskaya, Yuri Nikolsky, Erica L. Bauerlein, William C. Hahn, Rebecca S. Gelman, Craig Allred, Mina J. Bissell, Stuart Schnitt and Kornelia Polyak
[Summary]  [Fulltext]  [PDF] 
May 06, 2008 
13 (5)
11.  Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator
Sonia Lain, Jonathan J. Hollick, Johanna Campbell, Oliver D. Staples, Maureen Higgins, Mustapha Aoubala, Anna McCarthy, Virginia Appleyard, Karen E. Murray, Lee Baker, Alastair Thompson, Joanne Mathers, Stephen J. Holland, Michael J.R. Stark, Georgia Pass, Julie Woods, David P. Lane and Nicholas J. Westwood
[Summary]  [Fulltext]  [PDF] 
May 06, 2008 
13 (5)
12.  A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet, Stephen L. Archer, Joan Allalunis-Turner, Alois Haromy, Christian Beaulieu, Richard Thompson, Christopher T. Lee, Gary D. Lopaschuk, Lakshmi Puttagunta, Sandra Bonnet, Gwyneth Harry, Kyoko Hashimoto, Christopher J. Porter, Miguel A. Andrade, Bernard Thebaud and Evangelos D. Michelakis
[Summary]  [Fulltext]  [PDF] 
January,  
11 (1)
13.  The Inhibition of Tumor Cell Intravasation and Subsequent Metastasis via Regulation of In Vivo Tumor Cell Motility by the Tetraspanin CD151
Andries Zijlstra, John Lewis, Bernard DeGryse, Heidi Stuhlmann and James P. Quigley
[Summary]  [Fulltext]  [PDF] 
Mar 11, 2008 
13 (3)
14.  A Sweet New Role for EGFR in Cancer
Jeffrey A. Engelman and Lewis C. Cantley
[Summary]  [Fulltext]  [PDF] 
May 06, 2008 
13 (5)
15.  Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera
Gerlinde Wernig, Michael G. Kharas, Rachel Okabe, Sandra A. Moore, Dena S. Leeman, Dana E. Cullen, Maricel Gozo, Elizabeth P. McDowell, Ross L. Levine, John Doukas, Chi Ching Mak, Glenn Noronha, Michael Martin, Yon D. Ko, Benjamin H. Lee, Richard M. Soll, Ayalew Tefferi, John D. Hood and D. Gary Gilliland
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
16.  E2F1-Regulated MicroRNAs Impair TGFβ-Dependent Cell-Cycle Arrest and Apoptosis in Gastric Cancer
Fabio Petrocca, Rosa Visone, Mariadele Rapazzotti Onelli, Manisha H. Shah, Milena S. Nicoloso, Ivana de Martino, Dimitrios Iliopoulos, Emanuela Pilozzi, Chang-Gong Liu, Massimo Negrini, Luigi Cavazzini, Stefano Volinia, Hansjuerg Alder, Luigi P. Ruco, Gustavo Baldassarre, Carlo M. Croce and Andrea Vecchione
[Summary]  [Fulltext]  [PDF] 
Mar 11, 2008 
13 (3)
17.  HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
Rose Du, Kan V. Lu, Claudia Petritsch, Patty Liu, Ruth Ganss, Emmanuelle Passegué, Hanqiu Song, Scott VandenBerg, Randall S. Johnson, Zena Werb and Gabriele Bergers
[Summary]  [Fulltext]  [PDF] 
Mar 11, 2008 
13 (3)
18.  A Molecular View of Anti-ErbB Monoclonal Antibody Therapy
Daniel J. Leahy
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
19.  VHL Inactivation: A New Road to Senescence
William Y. Kim and Norman E. Sharpless
[Summary]  [Fulltext]  [PDF] 
Apr 08, 2008 
13 (4)
20.  p53 Activation: A Case against Sir
Christopher L. Brooks and Wei Gu
[Summary]  [Fulltext]  [PDF] 
May 06, 2008 
13 (5)