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On the cover: The cover image depicts immunofluorescence analysis of cytokeratin 5 (orange) and p53 (green) expression in human basal-like DCIS. Normal myoepithelial cells in the basal layer are positive for cytokeratin 5, whereas a subset of tumor epithelial cells are p53 positive. Double-positive cells in the basal layer are abnormal myoepithelial cells. For details, see Hu et al. (p. 394).
Featured Article
The Featured Article is freely available to all readers.
Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity
Zhang Weihua, Rachel Tsan, Wei-Chien Huang, Qiuyu Wu, Chao-Hua Chiu, Isaiah J. Fidler, and Mien-Chie Hung
Expression of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase associated with cell proliferation and survival, is overactive in many tumors of epithelial origin. Blockade of the kinase activity of EGFR has been used for cancer therapy; however, by itself, it does not seem to reach maximum therapeutic efficacy. We report here that in human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).
New Cell Press Podcast
In the new Cell Press podcast, we learn about a study in the April issue of Cancer Cell by Linda Chin that shows the concurrent loss of two key tumor suppressor genes in human glioblastomas. We hear about a study in the April 18th issue of Cell by Rudolph Jaenisch, in which mature B cells are reprogrammed to a pluripotent state. We also hear about how an insidious bacterial pathogen, Mycobacterium tuberculosis, subverts the host immune response, presented in the latest issue of Cell Host & Microbe. Finally, stay tuned for our quarterly roundup of exciting research highlights published in the Cell Press family of journals.
You can listen directly by clicking on the link below; the MP3 file will play in your preferred media player: http://podcast.cell.com/0418cell2008.mp3. To learn about other ways to listen to the podcast, click here.
Annotated Table of Contents
The Annotated Table of Contents for this issue is available here.
Focus Collection
Explore our collection of past Focus articles here.
Top 20 Articles
These are the Top 20 Papers by download from the Cancer Cell web site for the last 30 days. You can see the summaries if you are registered, or full text and PDFs if you have subscribed.
Announcements
Cell Press announces new partnership with the
Biophysical Society
Now published by Cell Press:
The American Journal of Human Genetics
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